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DETOX LIVER PATHWAYS #2 (DE2)
- Unit price
This kit contains signatures of liver sarcodes, (healthy, tissue and cells) disease nosodes as well as main liver detoxification pathways in Phase I and Phase II.
Alpha-1 Antitrypsin Deficiency
“A1ATD is the leading genetic cause of liver disease among children. It is a protein-folding disorder in which toxic insoluble ATZ proteins aggregate in the ER of hepatocytes leading to inflammation, fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780543/
Bile, a yellow-green fluid made by the liver, consists largely of cholesterol, bilirubin and bile salts. The salts are derived from bile acids: “Seventeen enzymes convert cholesterol into bile acids, which are transformed into bile salts by the association with Na+ or K+ ions.“ https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full Bile helps digest fats.
The biliary tract includes organs and ducts that make and store bile, and release it into the small intestine. The tract includes the gallbladder and bile ducts inside and outside the liver. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/biliary-tract
Cells – Hepatic Stellate Cells
“The stellate cell, previously known as the Ito cell, fat-storing cell, perisinusoidal cell or lipocyte, is a major storage site for vitamin A. In liver injury, it becomes a transitional cell or myofibroblast-like cell capable of synthesising collagen types I, III and IV as well as laminin.” https://www.sciencedirect.com/topics/medicine-and-dentistry/stellate-cell
Cells – Hepatocytes
About 70–85% of the liver volume is occupied by parenchymal hepatocytes. There are 4 major liver cell types: hepatocytes, hepatic stellate cells, Kupffer cells, liver sinusoidal endothelial cells. There are about 20 billion hepatocytes responsible for a range of metabolic activities.
Cells - Kupffer Cells
“Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771376/
Cells – Liver Sinusoidal Endothelial Cells (LSECs)
LSECs play a central role in the scavenging and clearance of blood borne waste. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542980/
LSECs have long been noted to contribute to liver regeneration after liver injury. https://www.jci.org/articles/view/66025
Glisson’s Capsule is named after 17th century British doctor Francis Glisson. It is a layer of loose connective tissue that surrounds the liver and its related arteries and ducts.
The three most common metabolic liver diseases are: hereditary hemochromatosis, Alpha-I antitrypsin deficiency (AATD), and Wilson Disease. Hemochromatosis is a disorder in which the body can build up too much iron in the skin, heart, liver, pancreas, pituitary gland, and joints.
The liver hilum is an opening or fissure located on the underside of the liver that accommodates veins, arteries, lymphatic structures, bile ducts, and nerves.
Hepatic Portal Vein
The blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas, and spleen to the liver.
The liver helps rid the body of bilirubin – a red-orange compound from the normal breakdown of red blood cells. When bilirubin is broken down, its metabolites are excreted through bile and urine. Excess bilirubin in the body causes the yellowing discoloration of skin and sclera of the eyes that is called jaundice.
Cirrhosis is scarring (fibrosis) of the liver caused by long-term liver damage. The scar tissue prevents the liver working properly.
Liver Detoxification, Phase I: Cytochrome P450 Enzymes
With its abundance of cytochrome P450 enzymes, the liver is the primary organ for detoxification. These enzymes are also present in small intestine, brain, heart, lungs, skin, and other tissues. “Phase 1 enzymes modify fat-soluble toxins via certain chemical reactions. Among these are oxidation, reduction, and hydrolysis. These reactions are what add or expose a place on the toxin for Phase 2 enzymes...” Phase 1 reactions produce many free radicals.
Liver Detoxification, Phase II: Sulfation
“Phase 2 detox is known as the conjugation pathway, whereby the liver attaches another molecule to the “intermediate toxin” to render is less harmful. There are 6 types of conjugation that takes place in this phase: sulfation, glucuronidation, glutathione conjugation, methylation, acetylation, and glycination.” This makes the toxins less reactive and more water-soluble and easier to excrete. Phase 2 liver detoxification neutralizes the byproducts of Phase I and other remaining toxins. https://www.kithandkinwellness.com/blog-posts/phase-two-detoxification
Liver Detoxification, Phase II: Methylation
Methylation detoxifies hormones, neurotransmitters, or toxins, by making them water soluble; detoxifies amines (serotonin, melatonin, histamine, tyramine, and all of the catecholamines: dopamine, norepinephrine, epinephrine), phenols (salicylic acid—aspirin, cannabinoids, estradiol, and BPA), and many more.
Liver Detoxification, Phase II: Acetylation
“The N-acetyltransferase (NAT) enzymes are responsible for acetylation. In acetylation, an acetyl Co-A molecule is added to toxins to either make them less active or to convert them into a more active intermediate form…. Acetylation also converts serotonin into melatonin and hence is essential to improve your sleep.” https://www.xcode.life/genes-and-detox/what-is-acetylation-and-how-does-it-help-detoxify-your-body
Liver Detoxification, Phase II: Amino Acid Conjugation
“Unique among drug metabolism pathways, amino acid conjugation involves initial formation of a xenobiotic acyl-CoA thioester that is then conjugated principally with glycine in humans.” https://pubmed.ncbi.nlm.nih.gov/17428148/
Liver Detoxification, Phase II: Glucuronidation
“Glucuronidation is a well-known phase II detoxification reaction that acts as a pathway for eliminating many drugs, endogenous substances (substances produced by the body) such as hormones, neurotransmitters, estrogens, mold toxins, and cancer-causing toxins.” https://www.xcode.life/genes-and-detox/what-is-glucuronidation/
Liver Detoxification, Phase II: Glutathione Conjugation
Persistent inflammation in the liver caused by disease or toxic exposures “sends nonstop signals to repair cells to continue depositing collagen. The extra collagen stiffens around tissue like it supposed to in the healthy liver…” However, if the inflammation continues and even more collagen is deposited, this would lead to stiffening or fibrosis, according to the Canadian Liver Foundation. https://liverfoundation.org/about-your-liver/how-liver-diseases-progress/fibrosis-scarring/
Liver, Left Lobe
The liver has four lobes, right, left quadrate and caudate lobes. This complex organ performs over 300 functions.
The lobules of liver, are small divisions of the live observed at the microscopic scale (histology). The hepatic lobule is a building block of the liver tissue, consisting of a portal triad, hepatocytes arranged in linear cords between a capillary network, and a central vein. https://en.wikipedia.org/wiki/Lobules_of_liver
Liver, Quadrate Lobe
Liver, Right Lobe
“The liver sinusoids are small blood vessels between rows of hepatocytes. They are lined with two types of cell, sinusoidal endothelial cells, and phagocytic Kupffer cells. The sinusoids convey oxygen-rich hepatic arterial blood and nutrient-rich portal venous blood to the hepatocytes and eventually drain into the central vein, which drains into the hepatic vein.” https://en.wikipedia.org/wiki/Liver_sinusoid
Compared with lymphoid tissues, the frequency of natural killer (NK) cells, NKT cells and γδ T cells among total lymphocytes is increased within the liver…” https://www.sciencedirect.com/science/article/abs/pii/S1471490604002716
Non-Alcoholic Fatty Liver Disease (NAFLD)
“Fat in the liver typically develops when a person consumes more fat and sugars than his or her body can handle. This is more common in people who are overweight or obese but can also occur in adults with healthy body weights. If fat builds up to more than 5% of the liver, then the liver is considered to be a fatty liver. Although having this condition may not cause any immediate harm, there is a concern that extra fat in the liver might make the liver vulnerable to further injury such as inflammation and scarring.” https://www.liver.ca/patients-caregivers/liver-diseases/fatty-liver-disease/
is an inflammation of your liver in reaction to certain substances to which you're exposed. Toxic hepatitis can be caused by alcohol, chemicals, drugs or nutritional supplements.
The three most common metabolic liver diseases are: hereditary hemochromatosis, Alpha-I antitrypsin deficiency (AATD), and Wilson Disease. Wilson's disease is a rare inherited disorder that causes copper to accumulate in your liver, brain and other vital organs. Most people with Wilson's disease are diagnosed between the ages of 5 and 35, but it can affect younger and older people, as well. caused by an inherited defect in the ATP7B gene
Quantity: 30 Vials
Note: Ergopathics test kits are not intended to diagnose, prevent, treat or cure any disease, disorder or abnormal physical state. The vials contain ethanol and water and the process used to imprint them with electromagnetic signatures has not been tested or validated by any scientific method and is not approved by any regulatory authority. They are intended for use solely by qualified providers to support wellness and manage stress.
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DETOX LIVER PATHWAYS #2 (DE2)
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